• The genetic architecture of protein interaction affinity and specificity

  Bendel, Alexandra M.; Faure, Andre J.; Klein, Dominique; Shimada, Kenji; Lyautey, Romane; Schiffelholz, Nicole; Kempf, Georg; Cavadini, Simone; Lehner, Ben, 1978-; Diss, Guillaume (Nature Research, 2024)

  The encoding and evolution of specificity and affinity in protein-protein interactions is poorly understood. Here, we address this question by quantifying how all mutations in one protein, JUN, alter binding to all other ...
• Theoretical assessment of indistinguishable peptides in mass spectrometry-based proteomics

  Elhamraoui, Zahra; Borràs, Eva; Wilhelm, Mathias; Sabidó Aguadé, Eduard, 1981- (American Chemical Society (ACS), 2024)

  Mass-spectrometry-based proteomics has advanced with the integration of experimental and predicted spectral libraries, which have significantly improved peptide identification in complex search spaces. However, challenges ...
• The Hog1 stress-activated protein kinase targets nucleoporins to control mRNA Export upon stress

  Regot Rodríguez de Mier, Sergi; Nadal Clanchet, Eulàlia de; Rodríguez-Navarro, Susana; Seisenbacher, Gerhard; González Novo, Alberto; Pérez-Fernandez, Jorge; Gadal, Olivier; Ammerer, Gustav; Posas Garriga, Francesc (American Society for Biochemistry and Molecular Biology (ASBMB), 2013)

  The control of mRNA biogenesis is exerted at several steps. In response to extracellular stimuli, stress-activated protein kinases (SAPK) modulate gene expression to maximize cell survival. In yeast, the Hog1 SAPK plays a ...
• Smokefree legislation effects on respiratory and sensory disorders: a systematic review and meta-analysis

  Rando-Matos, Yolanda; Pons-Vigués, Mariona; López, María José; Córdoba, Rodrigo; Ballve-Moreno, José Luis; Puigdomènech, Elisa; Benito-López, Vega Estíbaliz; Arias-Agudelo, Olga Lucía; López Grau, Mercè; Guardia-Riera, Anna; Trujillo, José Manuel; Martin Cantera, Carlos (Public Library of Science (PLoS), 2017)

  Aims. The aim of this systematic review and meta-analysis is to synthesize the available evidence in scientific papers of smokefree legislation effects on respiratory diseases and sensory and respiratory symptoms (cough, ...
• Evaluación de un programa piloto promotor de habilidades parentales desde una perspectiva de salud pública

  Ramos, Pilar; Vázquez, Noelia; Pasarín i Rua, M. Isabel; Artazcoz Lazcano, Lucía, 1963- (Elsevier, 2016)

  Objetivo. Evaluar el proceso y los resultados de la fase piloto del Programa de desarrollo de habilidades parentales para familias (PHP), una estrategia de promoción de la parentalidad positiva basada en la evidencia y ...
• Software-aided approach to investigate peptide structure and metabolic susceptibility of amide bonds in peptide drugs based on high resolution mass spectrometry

  Radchenko, Tatiana L., 1984-; Brink, Andreas; Siegrist, Yves; Kochansky, Christopher; Bateman, Alison; Fontaine, Fabien; Morettoni, Luca; Zamora Rico, Ismael (Public Library of Science (PLoS), 2017)

  Interest in using peptide molecules as therapeutic agents due to high selectivity and efficacy is increasing within the pharmaceutical industry. However, most peptide-derived drugs cannot be administered orally because of ...
• Adaptación cultural y validación de cuestionarios de salud: revisión y recomendaciones metodológicas

  Ramada Rodilla, José María, 1961-; Serra-Pujadas, Consol; Delclòs i Clanchet, Jordi, 1956- (Instituto Nacional de Salud Pública, 2013)

  La traducción simple de un cuestionario puede dar lugar a interpretaciones erróneas debido a diferencias culturales y de lenguaje. Cuando se utilicen cuestionarios desarrollados en otros países e idiomas en estudios ...
• Epigenetic mechanisms in respiratory muscle dysfunction of patients with chronic obstructive pulmonary disease

  Puig Vilanova, Ester, 1987-; Aguiló Espases, Rafael; Rodríguez-Fuster, Alberto; Martínez Llorens, Juana; Gea Guiral, Joaquim; Barreiro Portela, Esther (Public Library of Science (PLoS), 2014)

  Epigenetic events are differentially expressed in the lungs and airways of patients with chronic obstructive pulmonary disease (COPD). Moreover, epigenetic mechanisms are involved in the skeletal (peripheral) muscle ...
• Fasting shapes chromatin architecture through an mTOR/RNA Pol I axis

  Al-Refaie, Nada; Padovani, Francesco; Hornung, Johanna; Pudelko, Lorenz; Binando, Francesca; Carmen Fabregat, Andrea del; Zhao, Qiuxia; Towbin, Benjamin D.; Sarinay Cenik, Elif; Stroustrup, Nicholas; Padeken, Jan; Schmoller, Kurt M.; Cabianca, Daphne S. (Nature Research, 2024)

  Chromatin architecture is a fundamental mediator of genome function. Fasting is a major environmental cue across the animal kingdom, yet how it impacts three-dimensional (3D) genome organization is unknown. Here we show ...
• Identifying cancer cells from calling single-nucleotide variants in scRNA-seq data

  Marot-Lassauzaie, Valérie; Beneyto Calabuig, Sergi; Obermayer, Benedikt; Velten, Lars; Beule, Dieter; Haghverdi, Laleh (Oxford University Press, 2024)

  Motivation: Single-cell RNA sequencing (scRNA-seq) data are widely used to study cancer cell states and their heterogeneity. However, the tumour microenvironment is usually a mixture of healthy and cancerous cells and it ...
• The interferon γ pathway enhances pluripotency and X-chromosome reactivation in iPSC reprogramming

  Barrero Asencio, Mercedes; Lazarenkov, Aleksey; Blanco, Enrique; Palma, Luis G.; López Rubio, Anna V.; Bauer, Moritz, 1987-; Bigas Salvans, Anna; Di Croce, Luciano; Sardina, Jose Luis; Payer, Bernhard (American Association for the Advancement of Science (AAAS), 2024)

  Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) requires activation of the pluripotency network and resetting of the epigenome by erasing the epigenetic memory of the somatic state. In female mouse ...
• The relationship between nanoscale genome organization and gene expression in mouse embryonic stem cells during pluripotency transition

  Garate,, Ximena; Gómez García, Pablo Aurelio; Fernández Merino, Manuel; Cadevall Anglès, Marta; Zhu, Chenggan; Castells García, Àlvaro, 1991-; Ed-Daoui, Ilyas; Martin, Laura; Ochiai, Hiroshi; Neguembor, Maria Victoria; Cosma, Maria Pia (Oxford University Press, 2024)

  During early development, gene expression is tightly regulated. However, how genome organization controls gene expression during the transition from naïve embryonic stem cells to epiblast stem cells is still poorly understood. ...
• A deep learning method that identifies cellular heterogeneity using nanoscale nuclear features

  Carnevali, Davide; Zhong, Limei; González-Almela, Esther; Viana, Carlotta; Rotkevich, Mikhail; Wang, Aiping; Franco-Barranco, Daniel; González-Marfil, Aitor; Neguembor, Maria Victoria; Castells García, Àlvaro, 1991-; Arganda-Carreras, Ignacio; Cosma, Maria Pia (Springer, 2024)

  Cellular phenotypic heterogeneity is an important hallmark of many biological processes and understanding its origins remains a substantial challenge. This heterogeneity often reflects variations in the chromatin structure, ...
• Genome-scale quantification and prediction of pathogenic stop codon readthrough by small molecules

  Toledano, Ignasi; Supek, Fran; Lehner, Ben (Nature Research, 2024)

  Premature termination codons (PTCs) cause ~10-20% of inherited diseases and are a major mechanism of tumor suppressor gene inactivation in cancer. A general strategy to alleviate the effects of PTCs would be to promote ...
• In silico RNA isoform screening to identify potential cancer driver exons with therapeutic applications

  Anglada-Girotto, Miquel; Ciampi, Ludovica; Bonnal, Sophie; Head, Sarah A.; Miravet Verde, Samuel, 1992-; Serrano Pubull, Luis, 1982- (Nature Research, 2024)

  Alternative splicing is crucial for cancer progression and can be targeted pharmacologically, yet identifying driver exons genome-wide remains challenging. We propose identifying such exons by associating statistically ...
• Alzheimer's disease genetic pathways impact cerebrospinal fluid biomarkers and imaging endophenotypes in non-demented individuals

  Lorenzini, Luigi; Vilor Tejedor, Natàlia, 1988-; Gispert López, Juan Domingo; Barkhof, Frederik (Wiley, 2024)

  Introduction: Unraveling how Alzheimer's disease (AD) genetic risk is related to neuropathological heterogeneity, and whether this occurs through specific biological pathways, is a key step toward precision medicine. ...
• Five decades of occupational cancer epidemiology

  Turner, Michelle C.; Straif, Kurt; Kogevinas, Manolis; Schubauer-Berigan, Mary K. (Nordic Association of Occupational Safety and Health (NOROSH), 2024)

  Objective: In this discussion paper, we provide a narrative review of past and present occupational cancer studies in the journal with a viewpoint towards future occupational cancer research. Method: We reviewed all ...
• Barriers to global engagement for African researchers: A position paper from the Alliance for Medical Research in Africa (AMedRA)

  Gaye, Bamba; Lassale, Camille; Jobe, Modou (International Society of Global Health, 2024)
• Development of land use regression, dispersion, and hybrid models for prediction of outdoor air pollution exposure in Barcelona

  Domínguez, Alan; Dadvand, Payam; Cirach, Marta; Gascon Merlos, Mireia, 1984-; Raimbault, Bruno; Galmés, Toni; Goméz Herrera, Laura; Persavento, Cecilia; Samuelsson, Karl; Tonne, Cathryn; Nieuwenhuijsen, Mark J.; Sunyer Deu, Jordi; Basagaña Flores, Xavier; Rivas, Ioar (Elsevier, 2024)

  Background: Air pollution is the leading environmental risk factor for health. Assessing outdoor air pollution exposure with detailed spatial and temporal variability in urban areas is crucial for evaluating its health ...
• Sleep problems mediate the association between outdoor nighttime light and symptoms of depression and anxiety: A cross-sectional, multi-city study in Bulgaria

  Helbich, Marco; Burov, Angel; Dimitrova, Donka; Markevych, Iana; Nieuwenhuijsen, Mark J.; Dzhambov, Angel M. (Elsevier, 2024)

  Background: Nighttime light is a growing anthropogenic health threat, particularly in urban areas. Limited evidence suggests that exposure to outdoor artificial light at night (ALAN) may be associated with people's mental ...

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