Delivery of a sebum modulator by an engineered skin microbe in mice

Knödlseder, Nastassia; Fábrega, María José; Santos Moreno, Javier; Manils, Joan; Toloza, Lorena; Marín Vilar, Maria; Fernández Avilés, Cristina; Broadbent, Katrina; Maruotti, Julien; Lemenager, Hélène; Carolis, Carlo; Zouboulis, Christos C.; Soler Prat, Concepció; Lood, Rolf; Brüggemann, Holger; Güell Cargol, Marc, 1982-

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Delivery of a sebum modulator by an engineered skin microbe in mice

Document Type: Article

Version: Accepted version

Date: 2024

Name: Knodlseder_nb_deli.pdf

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Citation: Knödlseder N, Fábrega MJ, Santos-Moreno J, Manils J, Toloza L, Marín Vilar M, et al. Delivery of a sebum modulator by an engineered skin microbe in mice. Nat Biotechnol. 2024 Jan 9. DOI: 10.1038/s41587-023-02072-4

Permanent link: http://hdl.handle.net/10230/60285

Description:

Data de publicació electrònica: 09-01-2024

Abstract:

Microorganisms can be equipped with synthetic genetic programs for the production of targeted therapeutic molecules. Cutibacterium acnes is the most abundant commensal of the human skin, making it an attractive chassis to create skin-delivered therapeutics. Here, we report the engineering of this bacterium to produce and secrete the therapeutic molecule neutrophil gelatinase-associated lipocalin, in vivo, for the modulation of cutaneous sebum production.