• A New in vitro model to study the regulatory functions of β cells in early stages of type1 diabetes

  Pérez-González, Beatriz (Universitat Pompeu Fabra, 2024-12-13)

  Type 1 Diabetes (T1D) is an autoimmune disease marked by the selective destruction of pancreatic β cells. Early insulitis involves interactions between immune cells and β cells, but the mechanisms leading to β cell death ...
• Inference of selection acting on coding sequences in the human lineage

  Ali, Hossameldin (Universitat Pompeu Fabra, 2024-12-13)

  Selection forces have shaped the current human DNA sequence through evolution. These forces have been consistently changing, in magnitude and direction, across the different evolutionary episodes of the extant human lineage. ...
• Quantifying cellular behavior during early mammalian development

  Casaní Galdón, Pablo (Universitat Pompeu Fabra, 2024-12-13)

  In this thesis we study cell behaviours such as cellular decision making and self-organization using the developing mouse embryo as the system of study. To be able to extract the most needed cellular dynamics from experimental ...
• Interrogating the importance of x-chromosome inactivation and reactivation for meiotic potential

  Mattimoe, Tom (Universitat Pompeu Fabra, 2024-12-13)

  X-chromosome dosage compensation in female mammals is achieved through X-chromosome inactivation (XCI), where one X chromosome is epigenetically silenced to ensure dosage parity with male cells. During germline development, ...
• La monarquía franquista: discursos doctrinales y legislativos (1936-1947)

  Cerdà Serrano, Jordi (Universitat Pompeu Fabra, 2023-06-26)

  Esta tesis aborda cómo se construyó jurídicamente la monarquía de la Ley de Sucesión en la Jefatura del Estado (1947) en la España franquista desde una perspectiva tanto formal como doctrinal. Primero, considerando el ...
• Sleep in the preclinical stages of Alzheimer's disease: a multimodal biomarkers approach

  Stankeviciute, Laura (Universitat Pompeu Fabra, 2023-12-19)

  This Thesis delves into the intricate relationship between sleep disruptions and Alzheimer's disease (AD). Sleep disturbances are a prevalent feature of AD, and evidence suggests they may accelerate cognitive decline. ...
• When P. falciparum meets the brain microvasculature: a 3D blood-brain barrier model to study cerebral malaria

  Piatti, Livia (Universitat Pompeu Fabra, 2024-12-10)

  La alteración de la barrera hematoencefálica está relacionada con la malaria cerebral, una complicación de la infección por Plasmodium falciparum asociada con la acumulación del parásito en los vasos sanguíneos cerebrales. ...
• Analyzing the role of activated fibroblasts in the activation of macrophages

  Bruch Oms, Marina (Universitat Pompeu Fabra, 2022-12-15)

  Tumors are complex masses composed by multiple cell types, such as cancer associated fibroblasts (CAFs) and macrophages, that interact with each other promoting the tumor progression. Snail1 is a transcription factor ...
• The Functional role of theta oscillations in visual working memory performance

  Pileckyte, Indre (Universitat Pompeu Fabra, 2024-01-24)

  Oscillations at theta frequency (4-7 Hz) have been hypothesized to play an important functional role in brain processes associated to working memory. In this thesis, I investigate how the systematic manipulation of different ...
• The Representation and reception of mental and neurological disorders in Britidh-US coming-of-age dramedy TV series

  Lopera Marmol, Marta (Universitat Pompeu Fabra, 2023-02-06)

  Las representaciones de los trastornos mentales en las series de televisión han sido a menudo inexactas. Esta investigación tiene como objetivo analizar la representación y la recepción de los trastornos mentales y ...
• Phase-based signal analysis measures applied to electroencephalographic recordings from epilepsy patients

  Espinoso Palacín, Anaïs (Universitat Pompeu Fabra, 2024-01-22)

  This thesis presents new phase-based signal analysis techniques to study brain dynamics from patients with pharmacoresistant focalonset epilepsy. We analyze electroencephalographic (EEG) recordings from seizure and ...
• Empowering educators' inspiration during the learning design process with citizen science data and technology-enhanced learning

  Calvera Isabal, Miriam (Universitat Pompeu Fabra, 2024-11-28)

  The creation of learning designs (LD) represents a pivotal aspect of pedagogical practice, as it entails the integration of subject-matter knowledge with the pedagogical expertise of individual educators. Furthermore, the ...
• El Fantasma de lo real: relación cine-teatro en tres obras de investigación práctica. Estudio de las películas Kopfkino y Pienso casa digo silla de la Cía. Los Detectives y del Film Ensayo Bellas Artrópodas a través del cine de Jaques Rivette y Mariano Llinás

  García Vera, María (Universitat Pompeu Fabra, 2022-12-16)

  Esta tesis trata ciertas relaciones entre el cine y el teatro desde mi práctica escénica y fílmica como actriz y creadora. La perspectiva de género, la performatividad y la interdisciplinariedad (la traslación de códigos ...
• Dissecting motor behaviour alterations in Parkinson's disease using genetically modified zebrafish models

  Tzotzolaki, Tanita Maria (Universitat Pompeu Fabra, 2024-12-10)

  Los trastornos neurodegenerativos como la enfermedad de Parkinson (EP) implican la degeneración progresiva del sistema nervioso, lo que provoca alteraciones tanto motoras como cognitivas. La EP afecta a millones de personas ...
• Manual d'apocalíptica contemporània: Epistemologia, ontologia i ètica per a temps de tribulació

  Calvera Cabeza, Ignasi (Universitat Pompeu Fabra, 2024-11-27)

  The most recent technological advances, especially in the field of artificial intelligence (AI), have generated a new eschatological framework; now, however, of a secular nature. Philosophers, politicians, engineers, ...
• Temperature impacts on mortality at different spatial and temporal scales

  Quijal-Zamorano, Marcos (Universitat Pompeu Fabra, 2024-11-20)

  This PhD thesis investigates the relationship between temperature and mortality at different spatial and temporal scales, addressing a crucial issue in the context of rising temperatures due to anthropogenic climate change. ...
• Contributions to fully homomorphic encryption

  Rovira Cisterna, Sergi (Universitat Pompeu Fabra, 2024-07-22)

  In recent years, the field of Fully Homomorphic Encryption (FHE) has become one of the main pilars for privacy-preserving technologies. However, many challenges still remain to be tackled before this technology can be ...
• Plant processing activities and the use of domestic space at Neolithic Çatalhöyük, Turkey: A microbotanical perspective

  Santiago-Marrero, Carlos G. (Universitat Pompeu Fabra, 2023-04-12)

  Çatalhöyük is a 9,000-year-old settlement located in the Konya Plain, Turkey. Thanks to the remarkable preservation of its material culture, Çatalhöyük expanded our understanding of the neolithic lifeways in what was one ...
• Evaluation of tumor mutational burden in follicular lymphoma

  Lafuente Sánchez, Marta (Universitat Pompeu Fabra, 2024-12-03)

  El linfoma folicular (LF) es el subtipo más frecuente de linfoma no-Hodgkin indolente, caracterizado por un buen pronóstico a pesar de considerarse incurable. Sin embargo, algunos pacientes presentan un curso clínico más ...
• Sostenibilidad de los medios de comunicación investigación conceptual y operacional sobre la relevancia y el engagement

  Castells Fos, Llúcia (Universitat Pompeu Fabra, 2024-12-05)

  La sostenibilidad económica de los medios de comunicación es una prioridad para las sociedades democráticas. Ahora bien, en un entorno digital de alta competencia, es un hecho establecido que, por un lado, los medios han ...

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