Browsing by Author "Lafzi, Atefeh"

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  • Benchmarking single-cell RNA sequencing protocols for cell atlas projects
    Mereu, Elisabetta; Lafzi, Atefeh; Moutinho, Catia; Gut, Marta; Gut, Ivo Glynne; Heyn, Holger (Nature Research, 2020)
    Single-cell RNA sequencing (scRNA-seq) is the leading technique for characterizing the transcriptomes of individual cells in a sample. The latest protocols are scalable to thousands of cells and are being used to compile ...
  • Identity noise and adipogenic traits characterize dermal fibroblast aging
    Aznar Benitah, Salvador; Lafzi, Atefeh; Berenguer-Llergo, Antonio; Youssif, Catrin; Castellanos, Andrés; Solanas, Guiomar; Peixoto, Francisca Oliveira; Stephan-Otto Attolini, Camille; Prats, Neus; Aguilera, Mònica; Martín Caballero, Juan; Heyn, Holger; Aznar Benitah, Salvador (Elsevier, 2018)
    During aging, stromal functions are thought to be impaired, but little is known whether this stems from changes of fibroblasts. Using population- and single-cell transcriptomics, as well as long-term lineage tracing, we ...
  • The Polycomb-associated factor PHF19 controls hematopoietic stem cell state and differentiation
    Vizán, Pedro; Gutiérrez, Arantxa; Espejo, Isabel; García Montolío, Marc, 1991-; Lange, Martin; Carretero, Ana; Lafzi, Atefeh; Andrés Aguayo, Luisa de; Blanco, Enrique; Thambyrajah, Roshana; Graf, T. (Thomas); Heyn, Holger; Bigas Salvans, Anna; Di Croce, Luciano (American Association for the Advancement of Science (AAAS), 2020)
    Adult hematopoietic stem cells (HSCs) are rare multipotent cells in bone marrow that are responsible for generating all blood cell types. HSCs are a heterogeneous group of cells with high plasticity, in part, conferred by ...
  • Tutorial: guidelines for the experimental design of single-cell RNA sequencing studies
    Lafzi, Atefeh; Moutinho, Catia; Picelli, Simone; Heyn, Holger (Nature Research, 2018)
    Single-cell RNA sequencing is at the forefront of high-resolution phenotyping experiments for complex samples. Although this methodology requires specialized equipment and expertise, it is now widely applied in research. ...

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