• A New in vitro model to study the regulatory functions of β cells in early stages of type1 diabetes

  Pérez-González, Beatriz (Universitat Pompeu Fabra, 2024-12-13)

  Type 1 Diabetes (T1D) is an autoimmune disease marked by the selective destruction of pancreatic β cells. Early insulitis involves interactions between immune cells and β cells, but the mechanisms leading to β cell death ...
• Inference of selection acting on coding sequences in the human lineage

  Ali, Hossameldin (Universitat Pompeu Fabra, 2024-12-13)

  Selection forces have shaped the current human DNA sequence through evolution. These forces have been consistently changing, in magnitude and direction, across the different evolutionary episodes of the extant human lineage. ...
• Quantifying cellular behavior during early mammalian development

  Casaní Galdón, Pablo (Universitat Pompeu Fabra, 2024-12-13)

  In this thesis we study cell behaviours such as cellular decision making and self-organization using the developing mouse embryo as the system of study. To be able to extract the most needed cellular dynamics from experimental ...
• Interrogating the importance of x-chromosome inactivation and reactivation for meiotic potential

  Mattimoe, Tom (Universitat Pompeu Fabra, 2024-12-13)

  X-chromosome dosage compensation in female mammals is achieved through X-chromosome inactivation (XCI), where one X chromosome is epigenetically silenced to ensure dosage parity with male cells. During germline development, ...
• La monarquía franquista: discursos doctrinales y legislativos (1936-1947)

  Cerdà Serrano, Jordi (Universitat Pompeu Fabra, 2023-06-26)

  Esta tesis aborda cómo se construyó jurídicamente la monarquía de la Ley de Sucesión en la Jefatura del Estado (1947) en la España franquista desde una perspectiva tanto formal como doctrinal. Primero, considerando el ...

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